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Nat Prod Res. Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells. FEBS Lett. Ganoderma lucidum reduces kainic acid-induced hippocampal neuronal damage via inflammatory cytokines and glial fibrillary acid protein expression. Proc West Pharmacol Soc.

Ganoderma lucidum extract protects dopaminergic neurons through inhibiting the production of inflammatory mediators by activated microglia.

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Sheng Li Xue Bao. Epidemiological investigation on mental disorders in 7 areas of China. Hickie I, et al. Br J Psychiatry. Am J Psychiatry. Extract of Ganoderma lucidum prolongs sleep time in rats. Pharmacol Biochem Behav. Sleep-promoting effects of Ganoderma extracts in rats: Potentiation of ganodermic acid S on prostaglandin E 1 -induced cyclic AMP elevation in human platelets.

Thromb Res. Differential effects of ganodermic acid S on the thromboxane A2-signaling pathways in human platelets. Biochem Pharmacol. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum Ling-Zhi in healthy volunteers. Anesth Analg. Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs. Lipids Health Dis. Effect of oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.

Appl Environ Microbiol. Ganoderic acid and its derivatives as cholesterol synthesis inhibitors. Isolation and structure determination of a cholesterol esterase inhibitor from Ganoderma lucidum. J Microbiol Biotechnol. Metabolic fate of pancreas-derived cholesterol esterase in intestine: J Lipid Res.

Lipid-lowering effects of WAY,, an inhibitor of pancreatic cholesteryl ester hydrolase. Comb Chem High Throughput Screen. Hypoglycemic effect and mechanism of a proteoglycan from ganoderma lucidum on streptozotocin-induced type 2 diabetic rats. Eur Rev Med Pharmacol Sci. Antihyperglycemic effect of ganoderma lucidum polysaccharides on streptozotocin-induced diabetic mice.

Int J Mol Sci. Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells. J Cell Physiol. Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: Nat Med. J Natl Cancer Inst. Role of NK cells in the control of metastatic spread and growth of tumor cells in mice. Int J Cancer. The role of natural killer cells in the control of tumor growth and metastasis.

Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer. Effects of ganopoly a Ganoderma lucidum polysaccharide extract on the immune functions in advanced-stage cancer patients. Extraction of polysaccharide from Ganoderma lucidum and its immune enhancement activity. Int J Biol Macromol. Inhibition by fibrin coagulation of lung cancer cell destruction by human interleukinactivated killer cells. Jpn J Cancer Res. Ganoderma lucidum polysaccharides eradicates the blocking effect of fibrinogen on NK cytotoxicity against melanoma cells.

Oncol Lett. J Drug Target. Activation of mouse macrophages by the alkali-extracted polysaccharide from spore of Ganoderma lucidum. Ji Z, et al. Int J Med Mushrooms.

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Study on antitumor activity and mechanism of Ganoderma polysaccharides B. Submerged cultivation of Ganoderma lucidum biomass and immunostimulatory effects of fungal polysaccharides. J Biotechnol. Medicinal mushroom Lingzhi or Reishi, Ganoderma lucidum W. Effect of Ganoderma polysaccharides on inositol trisphosphate and diacylglycerol in murine peritoneal macrophages. Effect of ganoderma polysacchrides on PKC activity in murine peritoneal macrophages.

Protective effects of Ganoderma lucidum polysaccharides peptide on injury of macrophages induced by reactive oxygen species. Acta Pharmacol Sin. Preferential induction of Th17 cells in vitro and in vivo by Fucogalactan from Ganoderma lucidum Reishi. Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides.

Immunol Lett. Regulatory effect of Ganoderma lucidum polysaccharides on cytotoxic T-lymphocytes induced by dendritic cells in vitro. Nat Immunol. Sakaguchi S. J Appl Physiol. Immune changes induced by exercise in an adverse environment. Can J Physiol Pharmacol.

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Br J Sports Med. Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum Reishi polysaccharides: Life Sci. J Biol Chem. Control of B-cell responses by Toll-like receptors. Effect of medicinal plant extracts on forced swimming capacity in mice. Anti-androgenic activities of Ganoderma lucidum. Liu J, et al. Anti-androgen effects of extracts and compounds from Ganoderma lucidum. Chem Biodivers. The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum.

Ganoderic acid DM: Ganoderma lucidum is an inhibitor of testosterone-induced prostatic hyperplasia in rats. Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms. Asian J Androl. Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling. Int J Oncol. Ganoderol B: Fatmawati S, et al. The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum. Isolation and hypoglycemic activity of ganoderans A and B, glycans of Ganoderma lucidum fruit bodies.

Mechanisms of hypoglycemic activity of ganoderan B: Hypoglycemic effect of Ganoderma lucidum polysaccharides. HPLC analysis of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes activity and Bax, Bcl-2 expression. In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage.

A protein tyrosine phosphatase 1B activity inhibitor from the fruiting bodies of Ganoderma lucidum Fr. Karst and its hypoglycemic potency on streptozotocin-induced type 2 diabetic mice. Br J Nutr. ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK.

Effect of Ganoderma lucidum polysaccharides on hemodynamic and antioxidation in T2DM rats. Zhongguo Zhong Yao Za Zhi. Pharmacophore-based discovery of FXR-agonists. Part II: Farnesoid X receptor: J Med Chem. Study of potential cardioprotective effects of Ganoderma lucidum Lingzhi: Tie L, et al. Ganoderma lucidum polysaccharide accelerates refractory wound healing by inhibition of mitochondrial oxidative stress in type 1 diabetes.

Cell Physiol Biochem. Effect of polysaccharides from Ganoderma lucidum on streptozotocin-induced diabetic nephropathy in mice. An immunomodulating protein, Ling Zhi-8 LZ-8 prevents insulitis in non-obese diabetic mice. Protective effects of Ganoderma lucidum spore on cadmium hepatotoxicity in mice. Hepatoprotective effects of Ganoderma lucidum peptides against D-galactosamine-induced liver injury in mice.

Ganoderma lucidum protects liver mitochondrial oxidative stress and improves the activity of electron transport chain in carbon tetrachloride intoxicated rats. Hepatol Res. Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice. Effects of Ganoderma lucidum on obstructive jaundice-induced oxidative stress. Asian J Surg. Post-treatment of Ganoderma lucidum reduced liver fibrosis induced by thioacetamide in mice. Inhibitory effects of ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in cells and animal models.

Evaluation of antiproliferative activities and action mechanisms of extracts from two species of Ganoderma on tumor cell lines. Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum. Biotechnol Lett. Anti-hepatitis activities in the broth of Ganoderma lucidum supplemented with a Chinese herbal medicine.

Am J Chin Med. Bao PP, et al. PLoS One. Lloyd Aphyllophoromycetideae Products and Safety Concerns. Tomasi S, et al. Cytotoxic activity of methanol extracts from Basidiomycete mushrooms on murine cancer cell lines. Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL cells by the Ganoderma lucidum and Duchesnea chrysantha extracts. Cancer Lett. Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells. Leuk Res. Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells.

Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell. Effect of Ganoderma lucidum polysaccharides peptide on invasion of human lung carcinoma cells in vitro.

Beijing Da Xue Xue Bao. Effect of Ganoderma on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells. Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum. New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells. Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest.

Tumour cell adhesion and integrin expression affected by Ganoderma lucidum. Jiang J, et al. Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC The effect of a novel botanical agent TBS on invasive prostate cancer in animal models. Heller Ribes griffithii Hook. Gao Ribes hallii Jancz. Ribes haoi C. Ribes hendersonii C. Ribes henryi Franch. Ribes hesperium McClatchie Ribes heterotrichum C. Ribes himalense Royle ex Decne. Ribes hirtellum Michx. Ribes hirtum Willd.

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